rs6232

A SNP in the PCSK1 gene on chromosome 5. Its most notable genotype is C;C: Higher risk of obesity and insulin sensitivity

Gene
PCSK1
Location
Chr 596,416,081 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
2%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TGoodcommon in complete genomicsTypical · 0.097% of people
  2. C;TBadHigher risk of obesity and insulin sensitivityWorth knowing · 2.03% of people
  3. C;CMost notableBadHigher risk of obesity and insulin sensitivityWorth knowing · 2.10% of people

SNPedia records rs6232 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 9 HapMap populations.

  • AverageT;T 97% C;T 3% C;C 0%
  • European ancestry (Utah)T;T 91% C;T 9% C;C 0%
  • Han Chinese (Beijing)T;T 99% C;T <1% C;C 0%
  • Japanese (Tokyo)T;T 99% C;T <1% C;C 0%
  • Yoruba (Nigeria)T;T 100% C;T 0% C;C 0%
  • Gujarati IndianT;T 92% C;T 8% C;C 0%
  • Luhya (Kenya)T;T 99% C;T <1% C;C 0%
  • Mexican ancestry (Los Angeles)T;T 98% C;T 2% C;C 0%
  • Maasai (Kenya)T;T 98% C;T 2% C;C 0%
  • TuscanT;T 94% C;T 6% C;C 0%

Conditions, medicines and genes

Other PCSK1 SNPs

All PCSK1 SNPs

Notes

From SNPedia

Notes

*rs6232 G allele (in dbSNP orientation) linked to 1.34x increased risk of obesity *rs6234/rs6235 (or rs10515237) see also: spitoon Obesity: Preliminary Research

Source and license

Adapted from rs6232 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.