rs634552

A SNP in the SERPINH1 gene on chromosome 11. Its most notable genotype is T;T: AMD Association

Gene
SERPINH1
Location
Chr 1175,571,007 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GGoodNormalTypical · 0.046% of people
  2. T;TMost notableBadAMD AssociationMinor · 1.018% of people

On SNPedia: (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 46% T;T 18%
  • European ancestry (Utah)G;G 72% T;T 2%
  • Han Chinese (Beijing)G;G 43% T;T 25%
  • Japanese (Tokyo)G;G 24% T;T 24%
  • Yoruba (Nigeria)G;G 45% T;T 20%

Notes

From SNPedia

Notes

Single variant analysis of variants significantly associated with AMD risk

T;T

https://www.ncbi.nlm.nih.gov/pubmed/28347358

Source and license

Adapted from rs634552 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.