rs6356

A SNP in the TH gene on chromosome 11. Its most notable genotype is C;C: common in clinvar

Gene
TH
Location
Chr 112,169,721 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
42%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommon in clinvarTypical · 0.039% of people

SNPedia records rs6356 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 39%
  • European ancestry (Utah)C;C 43%
  • Han Chinese (Beijing)C;C 5%
  • Japanese (Tokyo)C;C 6%
  • Yoruba (Nigeria)C;C 83%
  • African ancestry (Southwest US)C;C 75%
  • Chinese (Denver)C;C 5%
  • Gujarati IndianC;C 20%
  • Luhya (Kenya)C;C 82%
  • Mexican ancestry (Los Angeles)C;C 25%
  • Maasai (Kenya)C;C 53%
  • TuscanC;C 37%

Other TH SNPs

All TH SNPs

Notes

From SNPedia

Show notes, about 190 words

Nicotine dependence in a prospective population-based study of adolescents: the protective role of a functional tyrosine hydroxylase polymorphism. Discovery of common human genetic variants of GTP cyclohydrolase 1 (GCH1) governing nitric oxide, autonomic activity, and cardiovascular risk. Dopa decarboxylase and tyrosine hydroxylase gene variants in suicidal behavior. A functional intronic variant in the tyrosine hydroxylase (TH) gene confers risk of essential hypertension in the Northern Chinese Han population. Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. Overview of the Rapid Response data. Analysis of 19 genes for association with type I diabetes in the Type I Diabetes Genetics Consortium families. Dopaminergic pathway gene polymorphisms and genetic susceptibility to schizophrenia among north Indians. Frequent sequence variant in the human tyrosine hydroxylase gene. Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism.

Source and license

Adapted from rs6356 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.