rs6426749

A SNP on chromosome 1. Its most notable genotype is G;G: common in complete genomics

Gene
None listed
Location
Chr 122,384,980 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in complete genomicsTypical · 0.056% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 56%
  • European ancestry (Utah)G;G 74%
  • Han Chinese (Beijing)G;G 58%
  • Japanese (Tokyo)G;G 46%
  • Yoruba (Nigeria)G;G 48%

Notes

From SNPedia

Notes

The regulatory model proposed in this paper suggests that the rs6426749(G) allele ultimately suppresses CDC42 expression, leading to (slightly) decreased bone mineral density and thereby increased osteoporosis incidence.

Source and license

Adapted from rs6426749 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.