rs6441286

A SNP in the IL12A-AS1 gene on chromosome 3. Its most notable genotype is G;G: 3.08x chance of developing primary biliary cirrhosis

Gene
IL12A-AS1
Location
Chr 3160,011,091 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad3.08x chance of developing primary biliary cirrhosisWorth knowing · 2.515% of people
  2. G;TBad1.54x chance of developing primary biliary cirrhosis.Worth knowing · 2.045% of people
  3. T;TGoodNormal chances of developing primary biliary cirrhosisMinor · 1.041% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 15% G;T 45% T;T 41%
  • European ancestry (Utah)G;G 13% G;T 48% T;T 38%
  • Han Chinese (Beijing)G;G 21% G;T 49% T;T 29%
  • Japanese (Tokyo)G;G 29% G;T 51% T;T 20%
  • Yoruba (Nigeria)G;G 3% G;T 36% T;T 61%
  • African ancestry (Southwest US)G;G 7% G;T 39% T;T 54%
  • Chinese (Denver)G;G 23% G;T 49% T;T 28%
  • Gujarati IndianG;G 15% G;T 51% T;T 34%
  • Luhya (Kenya)G;G 0% G;T 28% T;T 72%
  • Mexican ancestry (Los Angeles)G;G 17% G;T 48% T;T 35%
  • Maasai (Kenya)G;G 11% G;T 46% T;T 43%
  • TuscanG;G 20% G;T 46% T;T 34%

Conditions, medicines and genes

Other IL12A-AS1 SNPs

All IL12A-AS1 SNPs

Notes

From SNPedia

Notes

23andMe blog *Each G at rs2856683 increased the odds of primary biliary cirrhosis by 1.75x. *Each G at rs6441286 increased the odds of primary biliary cirrhosis by 1.54x. *Each A at rs3790567 increased the odds of primary biliary cirrhosis by 1.51x.

Source and license

Adapted from rs6441286 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.