rs6458307
A SNP in the GLTSCR1L gene on chromosome 6. Its most notable genotype is C;C: 1.4x risk
- Gene
- GLTSCR1L
- Location
- Chr 642,763,377 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 34%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableNot rated1.4x risk
- C;TNot rated0.8x risk
- G;GNot ratedNo summary available.
- T;TNot ratednormal
On SNPedia: (C;C), (C;T), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 39% C;T 44% G;G 0% T;T 17%
- European ancestry (Utah)C;C 49% C;T 37% G;G 0% T;T 14%
- Han Chinese (Beijing)C;C 53% C;T 43% G;G 0% T;T 4%
- Japanese (Tokyo)C;C 55% C;T 38% G;G 0% T;T 7%
- Yoruba (Nigeria)C;C 25% C;T 44% G;G 0% T;T 31%
- African ancestry (Southwest US)C;C 16% C;T 60% G;G 0% T;T 25%
- Chinese (Denver)C;C 63% C;T 34% G;G 0% T;T 3%
- Gujarati IndianC;C 51% C;T 38% G;G 0% T;T 12%
- Luhya (Kenya)C;C 23% C;T 47% G;G 0% T;T 30%
- Mexican ancestry (Los Angeles)C;C 41% C;T 53% G;G 0% T;T 5%
- Maasai (Kenya)C;C 11% C;T 46% G;G 0% T;T 43%
- TuscanC;C 42% C;T 42% G;G 0% T;T 16%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs6458307 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (T); the odds ratio associated with heterozygotes is 0.84 (CI 0.75-0.96), and for homozygotes, 1.39 (CI 1.13-1.69).
Source and license
Adapted from rs6458307 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.