rs646776

A SNP in the CELSR2 gene on chromosome 1. Its most notable genotype is T;T: 1.2x risk of coronary artery disease

Gene
CELSR2
Location
Chr 1109,275,908 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
21%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.2x risk of coronary artery diseaseWorth knowing · 2.159% of people

SNPedia records rs646776 on the minus strand: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 59%
  • European ancestry (Utah)T;T 55%
  • Han Chinese (Beijing)T;T 93%
  • Japanese (Tokyo)T;T 86%
  • Yoruba (Nigeria)T;T 45%
  • African ancestry (Southwest US)T;T 26%
  • Chinese (Denver)T;T 94%
  • Gujarati IndianT;T 56%
  • Luhya (Kenya)T;T 21%
  • Mexican ancestry (Los Angeles)T;T 71%
  • Maasai (Kenya)T;T 45%
  • TuscanT;T 62%

Conditions, medicines and genes

Other CELSR2 SNPs

All CELSR2 SNPs

Notes

From SNPedia

Notes

rs599839 and rs4970834 explain about 1% of the variation in circulating LDL-cholesterol levels. "When we look at this particular genetic variance, of all the cholesterol variation among the population, 1% of it can be attributed to this particular locus," said Sandhu. "This is equivalent to more established genes for LDL regulation, particularly APOE." rs646776 also linked. 23andMe blog coronary artery disease and heart attack SNP Risk Version Effect *rs646776 T 1.19 *rs17465637 C 1.14 *rs1746048 C 1.17 *rs6725887 C 1.17 *rs11206510 T 1.15 *rs3184504 T 1.13 *rs2306374 C 1.15 *rs3782886 C 1.44

Source and license

Adapted from rs646776 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.