rs6494696

A SNP on chromosome 15. Its most notable genotype is C;C: <0.71x risk for restless legs

Gene
None listed
Location
Chr 1567,810,868 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated<0.71x risk for restless legsTypical · 0.027% of people
  2. C;GNot rated0.71x risk for restless legsTypical · 0.045% of people
  3. G;GNot ratedcommonTypical · 0.028% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 27% C;G 45% G;G 28%
  • European ancestry (Utah)C;C 5% C;G 48% G;G 47%
  • Han Chinese (Beijing)C;C 48% C;G 47% G;G 5%
  • Japanese (Tokyo)C;C 52% C;G 38% G;G 10%
  • Yoruba (Nigeria)C;C 20% C;G 51% G;G 29%
  • African ancestry (Southwest US)C;C 25% C;G 42% G;G 33%
  • Chinese (Denver)C;C 48% C;G 42% G;G 10%
  • Gujarati IndianC;C 27% C;G 44% G;G 30%
  • Luhya (Kenya)C;C 16% C;G 49% G;G 36%
  • Mexican ancestry (Los Angeles)C;C 38% C;G 48% G;G 14%
  • Maasai (Kenya)C;C 10% C;G 43% G;G 47%
  • TuscanC;C 14% C;G 41% G;G 46%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6494696, a SNP located in a region of chromosome 15q, has been linked to a lower frequency of restless legs syndrome, a common sleep disorder, with an overall odds ratio of 0.71 (CI: 0.60-0.83) for the (C) minor allele. The association between this SNP and RLS has been replicated in three European populations.

Source and license

Adapted from rs6494696 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.