rs6495306

A SNP in the CHRNA5 gene on chromosome 15. Its most notable genotype is G;G.

Gene
CHRNA5
Location
Chr 1578,573,551 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
28%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedNo summary available.Worth knowing · 2.08% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 8%
  • European ancestry (Utah)G;G 21%
  • Han Chinese (Beijing)G;G 4%
  • Japanese (Tokyo)G;G <1%
  • Yoruba (Nigeria)G;G 7%
  • African ancestry (Southwest US)G;G 5%
  • Chinese (Denver)G;G 3%
  • Gujarati IndianG;G 8%
  • Luhya (Kenya)G;G 6%
  • Mexican ancestry (Los Angeles)G;G 10%
  • Maasai (Kenya)G;G 10%
  • TuscanG;G 10%

Other CHRNA5 SNPs

All CHRNA5 SNPs

Notes

From SNPedia

Notes

rs6495306 increases susceptibility to Substance dependence, Alcohol 1.43 times for carriers of the G allele

Source and license

Adapted from rs6495306 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.