rs6503319

A SNP in the MYH3 gene on chromosome 17. Its most notable genotype is C;C: normal risk of malaria

Gene
MYH3
Location
Chr 1710,670,842 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodnormal risk of malariaTypical · 0.041% of people
  2. C;TBad1.21x risk of malariaTypical · 0.045% of people
  3. T;TBad1.21x risk of malariaTypical · 0.014% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 41% C;T 45% T;T 14%
  • European ancestry (Utah)C;C 43% C;T 45% T;T 13%
  • Han Chinese (Beijing)C;C 46% C;T 42% T;T 13%
  • Japanese (Tokyo)C;C 39% C;T 51% T;T 10%
  • Yoruba (Nigeria)C;C 30% C;T 49% T;T 22%
  • African ancestry (Southwest US)C;C 33% C;T 46% T;T 21%
  • Chinese (Denver)C;C 39% C;T 48% T;T 13%
  • Gujarati IndianC;C 57% C;T 35% T;T 8%
  • Luhya (Kenya)C;C 30% C;T 45% T;T 25%
  • Mexican ancestry (Los Angeles)C;C 53% C;T 39% T;T 9%
  • Maasai (Kenya)C;C 41% C;T 49% T;T 10%
  • TuscanC;C 41% C;T 48% T;T 12%

Source and license

Adapted from rs6503319 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.