rs6503691

A SNP in the STAT5B gene on chromosome 17. Its most notable genotype is C;C: common

Gene
STAT5B
Location
Chr 1742,242,072 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
27%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodcommonTypical · 0.046% of people
  2. C;TNot ratedNo summary available.Typical · 0.037% of people
  3. T;TNot ratedNo summary available.Typical · 0.018% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 46% C;T 37% T;T 18%
  • European ancestry (Utah)C;C 79% C;T 21% T;T 0%
  • Han Chinese (Beijing)C;C 58% C;T 37% T;T 5%
  • Japanese (Tokyo)C;C 48% C;T 44% T;T 8%
  • Yoruba (Nigeria)C;C 8% C;T 43% T;T 49%
  • African ancestry (Southwest US)C;C 29% C;T 50% T;T 21%
  • Chinese (Denver)C;C 54% C;T 39% T;T 7%
  • Gujarati IndianC;C 51% C;T 41% T;T 9%
  • Luhya (Kenya)C;C 5% C;T 39% T;T 56%
  • Mexican ancestry (Los Angeles)C;C 79% C;T 17% T;T 3%
  • Maasai (Kenya)C;C 17% C;T 51% T;T 32%
  • TuscanC;C 78% C;T 21% T;T 2%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 130 words

breast cancer rs6503691 rs7211777 Carriers of the AC haplotype, which represents the variant alleles of both SNPs, were at an increased risk (OR = 1.41, 95% CI 1.09-1.82). A decreased risk was observed for carriers of the AT haplotype (OR = 0.60, 95% CI 0.38-0.94). Furthermore, individuals with the AC/GC diplotype were at a significantly increased risk (OR = 1.88, 95% CI 1.13-3.14) A polymorphism associated with STAT3 expression and response of chronic myeloid leukemia to interferon alpha. Association of signal transducer and activator of transcription 3 gene polymorphisms with cervical cancer in Chinese women. Association between polymorphisms in the signal transducer and activator of transcription and dilated cardiomyopathy in the Chinese Han population.

Source and license

Adapted from rs6503691 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.