rs6505162

A SNP in the MIR3184 gene on chromosome 17. Its most notable genotype is A;A: 0.43x decreased risk for esophageal cancer

Gene
MIR3184
Location
Chr 1730,117,165 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGood0.43x decreased risk for esophageal cancerWorth knowing · 2.130% of people
  2. A;CGood0.58x decreased risk for esophageal cancerWorth knowing · 2.039% of people
  3. C;CBadnormalMinor · 1.531% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 30% A;C 39% C;C 31%
  • European ancestry (Utah)A;A 30% A;C 58% C;C 12%
  • Han Chinese (Beijing)A;A 5% A;C 23% C;C 72%
  • Japanese (Tokyo)A;A 5% A;C 33% C;C 62%
  • Yoruba (Nigeria)A;A 62% A;C 34% C;C 3%
  • African ancestry (Southwest US)A;A 54% A;C 39% C;C 7%
  • Chinese (Denver)A;A 2% A;C 30% C;C 68%
  • Gujarati IndianA;A 23% A;C 44% C;C 34%
  • Luhya (Kenya)A;A 57% A;C 35% C;C 7%
  • Mexican ancestry (Los Angeles)A;A 12% A;C 52% C;C 36%
  • Maasai (Kenya)A;A 66% A;C 31% C;C 3%
  • TuscanA;A 18% A;C 51% C;C 31%

Notes

From SNPedia

Show notes, about 140 words

rs6505162 is a SNP located in the pre-miRNA region of mir423. The major allele is rs6505162(C). A study of 346 Caucasians with esophageal cancer found that compared with the homozygous wild-type genotype of rs6505162, individuals with the heterozygous and homozygous variant genotype had a significantly reduced esophageal cancer risk with odds ratios of 0.58 (CI: 0.41-0.82) and 0.43 (CI: 0.27-0.68), respectively. After stratifying by gender, smoking, and age, the authors discovered that the protective effect was significant only for individuals under 64 years of age, regardless of sex or whether they smoked. Other unfavorable genotypes (ie SNPs) were also identified that were not as significant as rs6505162, and the overall risk of esophageal cancer increased with increasing numbers of unfavorable SNPs. discussed in nature

Source and license

Adapted from rs6505162 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.