rs6539137

A SNP in the TXNRD1 gene on chromosome 12. Its most notable genotype is A;A: increased risk for and earlier onset in males of familial ALS

Gene
TXNRD1
Location
Chr 12104,313,402 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
5%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedincreased risk for and earlier onset in males of familial ALSTypical · 0.0<1% of people
  2. A;TNot ratedNo summary available.Typical · 0.05% of people
  3. T;TGoodnormalTypical · 0.094% of people

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A <1% A;T 5% T;T 94%
  • European ancestry (Utah)A;A 3% A;T 22% T;T 75%
  • Han Chinese (Beijing)A;A 0% A;T 0% T;T 100%
  • Japanese (Tokyo)A;A 0% A;T 0% T;T 100%
  • Yoruba (Nigeria)A;A 0% A;T 0% T;T 100%

Other TXNRD1 SNPs

All TXNRD1 SNPs

Notes

From SNPedia

Notes

rs6539137 is one of several TXNRD1 SNPs significantly associated with familial amyotrophic lateral sclerosis (FALS) but not sporadic amyotrophic lateral sclerosis (ALS). The risk allele, rs6539137(A), is also associated with an earlier age of onset by 8 years, and the shift was more significant in males (in fact, insignificant in females).

Source and license

Adapted from rs6539137 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.