rs6539267

A SNP in the POLR3B gene on chromosome 12. Its most notable genotype is C;C: normal

Gene
POLR3B
Location
Chr 12106,391,776 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
17%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.04% of people
  2. C;TGood0.79x risk of Tourette's syndromeTypical · 0.024% of people
  3. T;TGood0.79x risk of Tourette's syndromeTypical · 0.072% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 4% C;T 24% T;T 72%
  • European ancestry (Utah)C;C 12% C;T 32% T;T 57%
  • Han Chinese (Beijing)C;C 0% C;T 10% T;T 90%
  • Japanese (Tokyo)C;C 0% C;T 13% T;T 88%
  • Yoruba (Nigeria)C;C <1% C;T 19% T;T 81%
  • African ancestry (Southwest US)C;C 2% C;T 25% T;T 74%
  • Chinese (Denver)C;C 0% C;T 12% T;T 88%
  • Gujarati IndianC;C 13% C;T 36% T;T 52%
  • Luhya (Kenya)C;C 0% C;T 16% T;T 84%
  • Mexican ancestry (Los Angeles)C;C 2% C;T 32% T;T 67%
  • Maasai (Kenya)C;C 1% C;T 35% T;T 64%
  • TuscanC;C 11% C;T 38% T;T 52%

Other POLR3B SNPs

All POLR3B SNPs

Source and license

Adapted from rs6539267 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.