rs6564851

A SNP on chromosome 16. Its most notable genotype is G;G: higher beta-carotene levels

Gene
None listed
Location
Chr 1681,230,992 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
43%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableNot ratedhigher beta-carotene levelsTypical · 0.033% of people
  2. G;TNot ratedhigher beta-carotene levelsTypical · 0.045% of people
  3. T;TNot ratednormalTypical · 0.023% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 33% G;T 45% T;T 23%
  • European ancestry (Utah)G;G 32% G;T 50% T;T 19%
  • Han Chinese (Beijing)G;G 67% G;T 31% T;T 2%
  • Japanese (Tokyo)G;G 63% G;T 34% T;T 3%
  • Yoruba (Nigeria)G;G 10% G;T 44% T;T 45%
  • African ancestry (Southwest US)G;G 21% G;T 46% T;T 33%
  • Chinese (Denver)G;G 65% G;T 32% T;T 4%
  • Gujarati IndianG;G 23% G;T 43% T;T 34%
  • Luhya (Kenya)G;G 13% G;T 57% T;T 30%
  • Mexican ancestry (Los Angeles)G;G 39% G;T 49% T;T 12%
  • Maasai (Kenya)G;G 14% G;T 51% T;T 36%
  • TuscanG;G 12% G;T 58% T;T 30%

Notes

From SNPedia

Notes

rs6564851(G) associated with higher beta-carotene (p = 1.6 x 10(-24)) and alpha-carotene (p = 0.0001) levels and lower lycopene (0.003), zeaxanthin (p = 1.3 x 10(-5)), and lutein (p = 7.3 x 10(-15)) levels, with effect sizes ranging from 0.10-0.28 SDs per allele. Note that low plasma levels of carotenoids and tocopherols are associated with increased risk of chronic disease and disability, yet dietary intake of these lipid-soluble antioxidant vitamins is only poorly correlated with plasma levels, leading to the hypothesis that it isn't what you eat, it's your SNPs that regulate your carotenoid levels. This is one of the SNPs reported by NutraHacker.

Source and license

Adapted from rs6564851 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.