rs6602024
A SNP in the PFKP gene on chromosome 10. Its most notable genotype is A;A: 1-3 body mass index units heavier on average
- Gene
- PFKP
- Location
- Chr 103,113,045 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 11%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 2% A;G 18% G;G 80%
- European ancestry (Utah)A;A <1% A;G 18% G;G 81%
- Han Chinese (Beijing)A;A 0% A;G 3% G;G 97%
- Japanese (Tokyo)A;A 0% A;G <1% G;G 99%
- Yoruba (Nigeria)A;A 5% A;G 38% G;G 57%
- African ancestry (Southwest US)A;A 7% A;G 33% G;G 60%
- Chinese (Denver)A;A 0% A;G 4% G;G 96%
- Gujarati IndianA;A 0% A;G 9% G;G 91%
- Luhya (Kenya)A;A 6% A;G 30% G;G 65%
- Mexican ancestry (Los Angeles)A;A 0% A;G 19% G;G 81%
- Maasai (Kenya)A;A 5% A;G 25% G;G 70%
- TuscanA;A 0% A;G 21% G;G 79%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 170 words
* Within the PFKP gene, rs6602024 showed very strong association with BMI (p = 4.9 * 10-6). Homozygotes for the rare "A" allele of this SNP (minor allele frequency = 0.12) were 1.8 BMI units heavier than homozygotes for the common "G" allele. * They did not replicate association between rs6602024 and obesity-related traits in the GenNet sample, although they found that in European Americans, Hispanic Americans and African Americans, homozygotes for the rare "A" allele where, on average, 1.0 - 3.0 BMI units heavier than homozygotes for the more common "G" allele. Furthermore, a study of 18,000 Danish subjects also failed to find any direct role for this SNP in the development of obesity. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study.
Source and license
Adapted from rs6602024 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.