rs6603272

A SNP in the IL3RA gene on chromosome X. Its most notable genotype is G;G: >2.74x increased risk of developing schizophrenia

Gene
IL3RA
Location
Chr X1,352,245 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad>2.74x increased risk of developing schizophreniaWorth knowing · 2.024% of people
  2. G;TBad2.74x increased risk of developing schizophreniaWorth knowing · 2.035% of people
  3. T;TGoodNormal risk of developing schizophreniaMinor · 1.041% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 24% G;T 35% T;T 41%
  • European ancestry (Utah)G;G 11% G;T 36% T;T 53%
  • Han Chinese (Beijing)G;G 32% G;T 55% T;T 14%
  • Japanese (Tokyo)G;G 52% G;T 39% T;T 9%
  • Yoruba (Nigeria)G;G 0% G;T 11% T;T 89%

Conditions, medicines and genes

Notes

From SNPedia

Notes

This snp is in the Pseudoautosomal region. rs6603272, part of a haplotype block spanning introns 4, 5 and 6 of the IL3RA gene, has been reported in a whole genome association study to be associated with schizophrenia. (The other SNPs in this block are rs6422441 and rs17883192.) The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with this allele is 2.74.

Source and license

Adapted from rs6603272 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.