rs660339

A SNP in the UCP2 gene on chromosome 11. Its most notable genotype is G;G: common in clinvar

Gene
UCP2
Location
Chr 1173,978,059 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
43%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon in clinvarTypical · 0.033% of people

SNPedia records rs660339 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 33%
  • European ancestry (Utah)G;G 33%
  • Han Chinese (Beijing)G;G 33%
  • Japanese (Tokyo)G;G 19%
  • Yoruba (Nigeria)G;G 28%
  • African ancestry (Southwest US)G;G 37%
  • Chinese (Denver)G;G 29%
  • Gujarati IndianG;G 46%
  • Luhya (Kenya)G;G 34%
  • Mexican ancestry (Los Angeles)G;G 33%
  • Maasai (Kenya)G;G 31%
  • TuscanG;G 41%

Notes

From SNPedia

Show notes, about 250 words

Synergistic association of mitochondrial uncoupling protein (UCP) genes with schizophrenia. A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. Ala55Val polymorphism on UCP2 gene predicts greater weight loss in morbidly obese patients undergoing gastric banding. Lack of association between uncoupling protein-2 Ala55Val polymorphism and incident diabetes in the atherosclerosis risk in communities study. Ser1369Ala variant in sulfonylurea receptor gene ABCC8 is associated with antidiabetic efficacy of gliclazide in Chinese type 2 diabetic patients. Human uncoupling protein 2 and 3 genes are associated with obesity in Japanese. Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone. Polymorphisms of the UCP2 gene are associated with proliferative diabetic retinopathy in patients with diabetes mellitus. Prediction of successful weight reduction after laparoscopic adjustable gastric banding. Variation in the UCP2 and UCP3 genes associates with abdominal obesity and serum lipids: the Finnish Diabetes Prevention Study. Diabetes genes and prostate cancer in the Atherosclerosis Risk in Communities study. ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients. Polymorphisms of the UCP2 gene are associated with body fat distribution and risk of abdominal obesity in Spanish population.

Source and license

Adapted from rs660339 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.