rs6604026

A SNP in the RPL5 gene on chromosome 1. Its most notable genotype is C;C: >1.15x risk of multiple sclerosis

Gene
RPL5
Location
Chr 192,838,046 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad>1.15x risk of multiple sclerosisWorth knowing · 2.05% of people
  2. C;TBad1.15x risk of multiple sclerosisMinor · 1.528% of people
  3. T;TGoodcommonTypical · 0.067% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 5% C;T 28% T;T 67%
  • European ancestry (Utah)C;C 7% C;T 43% T;T 50%
  • Han Chinese (Beijing)C;C 0% C;T <1% T;T 99%
  • Japanese (Tokyo)C;C 0% C;T <1% T;T 99%
  • Yoruba (Nigeria)C;C 8% C;T 43% T;T 49%
  • African ancestry (Southwest US)C;C 7% C;T 37% T;T 56%
  • Chinese (Denver)C;C 0% C;T <1% T;T 99%
  • Gujarati IndianC;C 3% C;T 26% T;T 71%
  • Luhya (Kenya)C;C 12% C;T 46% T;T 42%
  • Mexican ancestry (Los Angeles)C;C 3% C;T 24% T;T 72%
  • Maasai (Kenya)C;C 9% C;T 44% T;T 47%
  • TuscanC;C 6% C;T 39% T;T 55%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6604026 has been reported in a large study to be associated with multiple sclerosis. The risk allele (oriented to the dbSNP entry) is (C); the odds ratio associated with this allele is 1.15 (CI 1.08-1.22).

C;C

Higher risk of multiple sclerosis

C;T

Slightly higher risk of multiple sclerosis

Source and license

Adapted from rs6604026 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.