rs6707530

A SNP in the FN1 gene on chromosome 2. Its most notable genotype is G;G: in colorectal cancer, may allow cancer cells to invade deeper layers

Gene
FN1
Location
Chr 2215,375,861 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBadin colorectal cancer, may allow cancer cells to invade deeper layersMinor · 1.127% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 27%
  • European ancestry (Utah)G;G 8%
  • Han Chinese (Beijing)G;G 66%
  • Japanese (Tokyo)G;G 74%
  • Yoruba (Nigeria)G;G 22%
  • African ancestry (Southwest US)G;G 12%
  • Chinese (Denver)G;G 61%
  • Gujarati IndianG;G 3%
  • Luhya (Kenya)G;G 14%
  • Mexican ancestry (Los Angeles)G;G 21%
  • Maasai (Kenya)G;G 12%
  • TuscanG;G 5%

Other FN1 SNPs

All FN1 SNPs

Notes

From SNPedia

Notes

. (2014 article) "SNP analysis indicated that 44 tumors with a GG genotype at SNP rs6707530 showed significantly higher FN1 expression than did 23 tumors with GT/TT genotypes (p<0.05). The product of the FN1 gene (located at 2q34) is involved in cell adhesion, migration and metastasis in mesenchymal tumors. Abundant expression of FN1 may allow cancer cells to invade deeper layers, which would eventually define tumor shape." (Abstract)

Source and license

Adapted from rs6707530 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.