rs6800901

A SNP in the POLQ gene on chromosome 3. Its most notable genotype is T;T: 1.3x multiple myeloma risk

Gene
POLQ
Location
Chr 3121,435,346 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
21%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;TBadmultiple myeloma risk ?Typical · 0.027% of people
  2. T;TMost notableBad1.3x multiple myeloma riskMinor · 1.15% of people

On SNPedia: (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;T 27% T;T 5%
  • European ancestry (Utah)C;T 40% T;T 11%
  • Han Chinese (Beijing)C;T 24% T;T 4%
  • Japanese (Tokyo)C;T 17% T;T 5%
  • Yoruba (Nigeria)C;T 17% T;T 0%
  • African ancestry (Southwest US)C;T 28% T;T 2%
  • Chinese (Denver)C;T 27% T;T 3%
  • Gujarati IndianC;T 26% T;T 12%
  • Luhya (Kenya)C;T 19% T;T 2%
  • Mexican ancestry (Los Angeles)C;T 31% T;T 5%
  • Maasai (Kenya)C;T 19% T;T 2%
  • TuscanC;T 53% T;T 6%

Source and license

Adapted from rs6800901 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.