rs683395

A SNP in the LAMP3 gene on chromosome 3. Its most notable genotype is T;T.

Gene
LAMP3
Location
Chr 3183,152,030 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
12%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. G;GNot rated1.3x riskTypical · 0.02% of people
  3. A;GBad1.5x riskTypical · 0.022% of people
  4. A;AGoodnormalTypical · 0.076% of people

SNPedia records rs683395 on the minus strand: (A;A), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 0% G;G 2% A;G 22% A;A 76%
  • European ancestry (Utah)T;T 0% G;G 0% A;G 19% A;A 81%
  • Han Chinese (Beijing)T;T 0% G;G 3% A;G 18% A;A 80%
  • Japanese (Tokyo)T;T 0% G;G <1% A;G 19% A;A 81%
  • Yoruba (Nigeria)T;T 0% G;G 6% A;G 29% A;A 65%
  • African ancestry (Southwest US)T;T 0% G;G 0% A;G 32% A;A 68%
  • Chinese (Denver)T;T 0% G;G 2% A;G 16% A;A 83%
  • Gujarati IndianT;T 0% G;G 0% A;G 16% A;A 84%
  • Luhya (Kenya)T;T 0% G;G 6% A;G 26% A;A 69%
  • Mexican ancestry (Los Angeles)T;T 0% G;G 0% A;G 12% A;A 88%
  • Maasai (Kenya)T;T 0% G;G 8% A;G 42% A;A 50%
  • TuscanT;T 0% G;G 0% A;G 15% A;A 85%

Conditions, medicines and genes

Other LAMP3 SNPs

All LAMP3 SNPs

Notes

From SNPedia

Notes

rs683395 has been reported in a large study to be associated with bipolar disorder. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.47 (CI 1.26-1.71), and for homozygotes, 1.3 (CI 0.69-2.46). Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort.

Source and license

Adapted from rs683395 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.