rs6836703

A SNP in the ART3 gene on chromosome 4. Its most notable genotype is A;A: 1.34x increased risk for azoospermia in males

Gene
ART3
Location
Chr 476,108,994 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot rated1.34x increased risk for azoospermia in malesTypical · 0.013% of people
  2. A;GNot rated1.34x increased risk for azoospermia in malesTypical · 0.042% of people
  3. G;GNot ratednormalTypical · 0.045% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageA;A 13% A;G 42% G;G 45%
  • European ancestry (Utah)A;A 0% A;G 23% G;G 77%
  • Han Chinese (Beijing)A;A 29% A;G 42% G;G 29%
  • Japanese (Tokyo)A;A 18% A;G 55% G;G 27%
  • Yoruba (Nigeria)A;A 7% A;G 47% G;G 47%

Conditions, medicines and genes

Other ART3 SNPs

All ART3 SNPs

Notes

From SNPedia

Notes

rs6836703 is one of several tightly linked SNPs in the ART3 gene found in a study of ~400 infertile males to be associated with somewhat increased risk of the type of male infertility known as non-obstructive azoospermia. The odds ratio reported for rs6836703(A) carriers is 1.34 (CI:1.11–1.63, p=0.0025). An almost equivalent ART3 SNP is rs14773, for which it's also the minor allele ((C) in this case) reported to represent increased risk for azoospermia and which is in tight linkage with rs6836703. Two other ART3 SNPs, rs11097230 and rs17001385, also achieved statistical significance, yet for them, the minor alleles were associated with reduced risk for azoospermia.

Source and license

Adapted from rs6836703 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.