rs6837793

A SNP in the NPY1R gene on chromosome 4. Its most notable genotype is A;A: normal

Gene
NPY1R
Location
Chr 4163,335,583 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.03% of people
  2. A;GBadmore likely to gain weight if taking risperidoneTypical · 0.021% of people
  3. G;GBadmore likely to gain weight if taking risperidoneTypical · 0.076% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 3% A;G 21% G;G 76%
  • European ancestry (Utah)A;A <1% A;G 19% G;G 81%
  • Han Chinese (Beijing)A;A 0% A;G 3% G;G 97%
  • Japanese (Tokyo)A;A 0% A;G 2% G;G 98%
  • Yoruba (Nigeria)A;A 13% A;G 44% G;G 43%
  • African ancestry (Southwest US)A;A 4% A;G 37% G;G 60%
  • Chinese (Denver)A;A 0% A;G 2% G;G 98%
  • Gujarati IndianA;A 0% A;G 16% G;G 84%
  • Luhya (Kenya)A;A 8% A;G 46% G;G 46%
  • Mexican ancestry (Los Angeles)A;A 0% A;G 11% G;G 90%
  • Maasai (Kenya)A;A 6% A;G 35% G;G 59%
  • TuscanA;A 1% A;G 22% G;G 78%

Conditions, medicines and genes

Other NPY1R SNPs

All NPY1R SNPs

Notes

From SNPedia

Notes

rs6837793 is a SNP associated with the NPY5 receptor gene, located in the single promoter region likely to be co-regulating the Y1 and Y5 receptor genes. In a study of 101 mostly Caucasian patients prescribed the atypical antipsychotic risperidone, carriers of a rs6837793(G) allele were more likely to gain significant weight compared to rs6837793(A;A) carriers, as assessed by physiogenomic analysis of corresponding weight profiles. Two other SNPs, rs8179183 and rs705381, were also significantly associated with weight profiles in these patients.

Source and license

Adapted from rs6837793 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.