rs6869366

A SNP in the TMEM167A gene on chromosome 5. Its most notable genotype is G;G: >2x increased risk for bladder cancer

Gene
TMEM167A
Location
Chr 583,075,927 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
10%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad>2x increased risk for bladder cancerTypical · 0.02% of people
  2. G;TBad2x increased risk for bladder cancerTypical · 0.021% of people
  3. T;TGoodnormalTypical · 0.078% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageG;G 2% G;T 21% T;T 78%
  • European ancestry (Utah)G;G 0% G;T 8% T;T 92%
  • Han Chinese (Beijing)G;G 0% G;T 20% T;T 80%
  • Japanese (Tokyo)G;G 4% G;T 22% T;T 73%
  • Yoruba (Nigeria)G;G 2% G;T 33% T;T 65%

Conditions, medicines and genes

Other TMEM167A SNPs

All TMEM167A SNPs

Notes

From SNPedia

Notes

rs6869366, also known as G-1394T, is a SNP in the DNA repair XRCC4 gene. A study of 158 Taiwanese patients found an association between carriers of a rs6869366(G) allele and increased risk for bladder cancer. The odds ratio was 2x for heterozygotes; no (T;T) homozygotes were seen in this study. Risk was further studied based on smoking history. Smokers who were also rs6869366(T) carriers were at even higher risk (crude OR=3.29, CI: 1.21-8.90, adjusted OR=3.35, CI=1.41-8.49), implying a gene-smoking interaction.

Source and license

Adapted from rs6869366 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.