rs6873545

A SNP in the GHR gene on chromosome 5. Its most notable genotype is C;C: d3/d3GHR homozygote; possibly longer longevity, at least in males

Gene
GHR
Location
Chr 542,631,162 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodd3/d3GHR homozygote; possibly longer longevity, at least in malesWorth knowing · 2.09% of people
  2. T;TGoodcommon/normalTypical · 0.050% of people

On SNPedia: (C;C), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 9% T;T 50%
  • European ancestry (Utah)C;C 8% T;T 52%
  • Han Chinese (Beijing)C;C 2% T;T 67%
  • Japanese (Tokyo)C;C <1% T;T 72%
  • Yoruba (Nigeria)C;C 18% T;T 25%
  • African ancestry (Southwest US)C;C 28% T;T 14%
  • Chinese (Denver)C;C <1% T;T 72%
  • Gujarati IndianC;C 4% T;T 63%
  • Luhya (Kenya)C;C 16% T;T 37%
  • Mexican ancestry (Los Angeles)C;C 2% T;T 67%
  • Maasai (Kenya)C;C 19% T;T 29%
  • TuscanC;C 3% T;T 54%

Other GHR SNPs

All GHR SNPs

Notes

From SNPedia

Notes

rs6873545 is one of several SNPs in the GHR gene that correlates with the presence or absence of exon 3 and thus the (germline) allele known as the d3-GHR allele. The rs6873545(T) allele correlates with the more common allele containing exon 3; rs6873545(C) correlates with the less common d3-GHR allele lacking exon 3.

C;C

see discussion at GHR

Source and license

Adapted from rs6873545 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.