rs6896702

A SNP in the SEMA5A gene on chromosome 5. Its most notable genotype is T;T: Increased risk of developing Parkinson's Disease

Gene
SEMA5A
Location
Chr 59,331,736 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodNormal risk of developing Parkinson's DiseaseMinor · 1.019% of people
  2. C;TBadSlightly increased risk of developing Parkinson's DiseaseMinor · 1.537% of people
  3. T;TMost notableBadIncreased risk of developing Parkinson's DiseaseWorth knowing · 2.044% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 19% C;T 37% T;T 44%
  • European ancestry (Utah)C;C 4% C;T 26% T;T 71%
  • Han Chinese (Beijing)C;C 7% C;T 33% T;T 60%
  • Japanese (Tokyo)C;C 8% C;T 45% T;T 47%
  • Yoruba (Nigeria)C;C 44% C;T 42% T;T 14%
  • African ancestry (Southwest US)C;C 32% C;T 52% T;T 16%
  • Chinese (Denver)C;C 5% C;T 32% T;T 63%
  • Gujarati IndianC;C 7% C;T 32% T;T 61%
  • Luhya (Kenya)C;C 51% C;T 37% T;T 13%
  • Mexican ancestry (Los Angeles)C;C 14% C;T 36% T;T 50%
  • Maasai (Kenya)C;C 35% C;T 48% T;T 17%
  • TuscanC;C 4% C;T 26% T;T 71%

Notes

From SNPedia

Notes

rs6896702 is in linkage disequilibrium with a polymorphism that increases susceptibility to Parkinson's disease 1.74 times for carriers of the T allele

Source and license

Adapted from rs6896702 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.