rs6897876

A SNP on chromosome 5. Its most notable genotype is C;C: slight increase in testicular cancer risk for men

Gene
None listed
Location
Chr 5142,308,074 (GRCh38)
Highest magnitude
1.2Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadslight increase in testicular cancer risk for menMinor · 1.227% of people
  2. C;TBadslight increase in testicular cancer risk for menMinor · 1.145% of people
  3. T;TGoodnormalTypical · 0.028% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 27% C;T 45% T;T 28%
  • European ancestry (Utah)C;C 21% C;T 48% T;T 31%
  • Han Chinese (Beijing)C;C 7% C;T 37% T;T 57%
  • Japanese (Tokyo)C;C 8% C;T 40% T;T 52%
  • Yoruba (Nigeria)C;C 45% C;T 45% T;T 10%
  • African ancestry (Southwest US)C;C 39% C;T 47% T;T 14%
  • Chinese (Denver)C;C 7% C;T 41% T;T 51%
  • Gujarati IndianC;C 33% C;T 53% T;T 15%
  • Luhya (Kenya)C;C 36% C;T 48% T;T 16%
  • Mexican ancestry (Los Angeles)C;C 35% C;T 47% T;T 19%
  • Maasai (Kenya)C;C 24% C;T 52% T;T 24%
  • TuscanC;C 42% C;T 41% T;T 17%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Testicular germ cell tumor risk I("TGCT"; i.e. testicular cancer risk) was increased 40% per copy of the major allele (C) at rs4324715 and rs6897876 (OR = 1.37, CI: 1.14–1.64; OR = 1.39, CI: 1.16–1.66, respectively), based on a genome-wide scan of 277 primarily Caucasian TGCT cases and 919 controls. Men who have two copies of the common version of the sprouty 4 SPRY4 gene have a 1.5-fold higher risk of testicular cancer than men who have two copies of the less common or minor version of the gene.

Source and license

Adapted from rs6897876 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.