rs6918698

A SNP in the CTGF gene on chromosome 6. Its most notable genotype is C;C: normal risk

Gene
CTGF
Location
Chr 6131,952,117 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
50%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormal riskTypical · 0.022% of people
  2. C;GNot rated~normal riskTypical · 0.052% of people
  3. G;GBad2.2x higher systemic sclerosis riskTypical · 0.026% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 4 HapMap populations.

  • AverageC;C 22% C;G 52% G;G 26%
  • European ancestry (Utah)C;C 21% C;G 44% G;G 36%
  • Han Chinese (Beijing)C;C 21% C;G 55% G;G 25%
  • Japanese (Tokyo)C;C 23% C;G 54% G;G 23%
  • Yoruba (Nigeria)C;C 23% C;G 58% G;G 19%

Conditions, medicines and genes

Other CTGF SNPs

All CTGF SNPs

Notes

From SNPedia

Notes

rs6918698, a common SNP located in the promoter of the CTGF gene, has been linked to increased risk for systemic sclerosis (scleroderma) based on a study of 500 Caucasian patients. The odds ratio is 2.2 for (G;G) homozygotes (p<0.001). The reason that the (C) allele appears to be protective is thought to be due to decreased CTGF activity.

Source and license

Adapted from rs6918698 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.