rs6976

A SNP in the GLT8D1 gene on chromosome 3. Its most notable genotype is C;C: No increased risk of osteoarthritis

Gene
GLT8D1
Location
Chr 352,694,788 (GRCh38)
Highest magnitude
1.0Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
38%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGoodNo increased risk of osteoarthritisMinor · 1.048% of people
  2. C;TBadslight risk of osteoarthritisMinor · 1.039% of people
  3. T;TBadrisk of osteoarthritisMinor · 1.014% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 48% C;T 39% T;T 14%
  • European ancestry (Utah)C;C 43% C;T 46% T;T 11%
  • Han Chinese (Beijing)C;C 26% C;T 56% T;T 18%
  • Japanese (Tokyo)C;C 27% C;T 48% T;T 26%
  • Yoruba (Nigeria)C;C 78% C;T 20% T;T 1%
  • African ancestry (Southwest US)C;C 63% C;T 35% T;T 2%
  • Chinese (Denver)C;C 29% C;T 57% T;T 14%
  • Gujarati IndianC;C 54% C;T 41% T;T 6%
  • Luhya (Kenya)C;C 78% C;T 19% T;T 3%
  • Mexican ancestry (Los Angeles)C;C 19% C;T 41% T;T 40%
  • Maasai (Kenya)C;C 84% C;T 15% T;T <1%
  • TuscanC;C 24% C;T 46% T;T 30%

Notes

From SNPedia

Notes

Research reported in the Lancet: "identified five genome-wide significant loci (binomial test p&#8804;5&#183;0&#215;10&#8722;8) for association with osteoarthritis and three loci just below this threshold. The strongest association was on chromosome 3 with rs6976 (odds ratio 1&#183;12 [95% CI 1&#183;08&#8212;1&#183;16]; p=7&#183;24&#215;10&#8722;11), which is in perfect linkage disequilibrium with rs11177. This SNP encodes a missense polymorphism within the nucleostemin-encoding gene GNL3. Levels of nucleostemin were raised in chondrocytes from patients with osteoarthritis in functional studies."

Source and license

Adapted from rs6976 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.