rs699
A SNP in the AGT gene on chromosome 1. Its most notable genotype is G;G: increased risk of hypertension
- Gene
- AGT
- Location
- Chr 1230,710,048 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 34%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableBadincreased risk of hypertension
- A;GBadincreased risk of hypertension
- A;ANot ratednormal risk of hypertension
SNPedia records rs699 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 56% A;G 33% A;A 11%
- European ancestry (Utah)G;G 20% A;G 43% A;A 37%
- Han Chinese (Beijing)G;G 64% A;G 30% A;A 6%
- Japanese (Tokyo)G;G 67% A;G 32% A;A <1%
- Yoruba (Nigeria)G;G 85% A;G 15% A;A 0%
- African ancestry (Southwest US)G;G 63% A;G 30% A;A 7%
- Chinese (Denver)G;G 62% A;G 31% A;A 6%
- Gujarati IndianG;G 38% A;G 49% A;A 14%
- Luhya (Kenya)G;G 80% A;G 19% A;A <1%
- Mexican ancestry (Los Angeles)G;G 47% A;G 45% A;A 9%
- Maasai (Kenya)G;G 71% A;G 28% A;A 1%
- TuscanG;G 21% A;G 43% A;A 36%
Related
Conditions, medicines and genes
Other AGT SNPs
- rs74315283C;TCarrier for a renal tubular dysgenesis mutationImportant
- rs121912702A;GCarrier for a renal tubular dysgenesis mutationImportant
- rs387906578-;ACarrier for a renal tubular dysgenesis mutationImportant
- rs4762G;Gnormal riskTypical
- rs5050T;Tcommon in clinvarTypical
- rs5051C;Cnormal riskTypical
- rs7079G;Gcommon in clinvarTypical
- rs1926723T;Tcommon in clinvarTypical
Notes
From SNPedia
Show notes, about 180 words
rs699 is a SNP in the angiotensin AGT gene that encodes a functional change. In most published literature, the name for this SNP is M235T, or perhaps Met235Thr, however its amino acid 268 (not 235) that varies based on the numbering in todays databases. rs699 is also occasionally known as C4072T. In any case, the rs699(C) allele encodes the threonine variant, which is associated with higher plasma angiotensin levels, and ultimately higher blood pressure leading to increased risk for hypertension associated disorders. This association was first reported in 1992 , and many studies, though not all, have replicated these findings. rs699 is also (generally) reported to be in tight linkage with rs5051, a neighboring SNP in the promoter of the AGT gene. rs699(C) has also been implicated as a risk allele in at least two Caucasian populations for pre-eclampsia (pregnancy-induced hypertension)PMID 8513325, PMID 8348146 but did not present a risk in one African population . A haplotype of rs4311, rs4343, rs699 increases risk of diabetic nephropathy 4x.
Source and license
Adapted from rs699 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.