rs6997709

A SNP on chromosome 8. Its most notable genotype is G;G: 1.5x higher risk for hypertension

Gene
None listed
Location
Chr 8139,167,781 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableBad1.5x higher risk for hypertensionWorth knowing · 2.070% of people
  2. G;TBad1.2x higher risk for hypertensionWorth knowing · 2.027% of people
  3. T;TNot ratednormalTypical · 0.03% of people

On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 70% G;T 27% T;T 3%
  • European ancestry (Utah)G;G 54% G;T 37% T;T 9%
  • Han Chinese (Beijing)G;G 80% G;T 19% T;T <1%
  • Japanese (Tokyo)G;G 89% G;T 11% T;T 0%
  • Yoruba (Nigeria)G;G 80% G;T 19% T;T 1%
  • African ancestry (Southwest US)G;G 68% G;T 32% T;T 0%
  • Chinese (Denver)G;G 83% G;T 17% T;T 0%
  • Gujarati IndianG;G 64% G;T 32% T;T 4%
  • Luhya (Kenya)G;G 76% G;T 20% T;T 4%
  • Mexican ancestry (Los Angeles)G;G 64% G;T 31% T;T 5%
  • Maasai (Kenya)G;G 60% G;T 37% T;T 4%
  • TuscanG;G 51% G;T 42% T;T 7%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs6997709 has been reported in a large study to be associated with high blood pressure. The risk allele (oriented to the dbSNP entry) is (G); the odds ratio associated with heterozygotes is 1.20 (CI 0.94-1.52), and for homozygotes, 1.49 (CI 1.18-1.89). In a study of 7,551 Koreans, this SNP was associated with systolic and diastolic blood pressures in a quantitative trait association test but no associations were found using a case-control association test.

Source and license

Adapted from rs6997709 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.