rs700651

A SNP in the BOLL gene on chromosome 2. Its most notable genotype is G;G: ~1.23x increased risk of intracranial aneurysm

Gene
BOLL
Location
Chr 2197,766,990 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
30%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodNormal risk of aneurysmMinor · 1.059% of people
  2. A;GBad~1.11x increased risk of intracranial aneurysmMinor · 1.533% of people
  3. G;GMost notableBad~1.23x increased risk of intracranial aneurysmWorth knowing · 2.08% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageA;A 59% A;G 33% G;G 8%
  • European ancestry (Utah)A;A 49% A;G 43% G;G 8%
  • Han Chinese (Beijing)A;A 47% A;G 36% G;G 18%
  • Japanese (Tokyo)A;A 23% A;G 55% G;G 23%
  • Yoruba (Nigeria)A;A 92% A;G 8% G;G 0%
  • African ancestry (Southwest US)A;A 72% A;G 26% G;G 2%
  • Chinese (Denver)A;A 31% A;G 51% G;G 18%
  • Gujarati IndianA;A 34% A;G 59% G;G 7%
  • Luhya (Kenya)A;A 88% A;G 11% G;G <1%
  • Maasai (Kenya)A;A 95% A;G 5% G;G 0%
  • TuscanA;A 65% A;G 32% G;G 3%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 170 words

a larger meta-analysis in 2013 gave rs700651 a per allele OR of 1.11; 95% CI 1.06 -1.18. See PMC3716358 23andMe blog aneurysm *rs700651 2 G 1.18x risk 1.56x risk *rs10958409 8 A 1.37x risk 1.79x risk *rs1333040 9 T 1.29x risk 1.67x risk Increased risk of intracranial (brain aneurysm) with certain SNPs. rs700651(G;G) associated with 1.56x risk of developing an intracranial aneurysm (IA). Heterozygote risk is 1.18x. Other SNPs associated with increased risk of developing IA include rs1333040 and rs10958409. rs10958409 is located on chromosome 9; rs1333040 is located on chromosome 8; rs700651 is located on chromosome 2. Unfortunately, the first sign of an intracranial aneurysm is rupture. Catastrophic bleeding and death may result. Specific knowledge of risk may influence screening decision. More information: Intracranial aneurysm screening: indications and advice for practice. .

A;G

Per Allele OR 1.11; CI 95% 1.06 - 1.18. See PMC3716358

G;G

Per Allele OR 1.11; CI 95% 1.06 - 1.18. See PMC3716358

Source and license

Adapted from rs700651 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.