rs7017300

A SNP on chromosome 8. Its most notable genotype is A;A: normal risk

Gene
None listed
Location
Chr 8127,513,023 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
22%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratednormal riskTypical · 0.060% of people
  2. A;CBad1.7x increased risk for prostate cancerTypical · 0.033% of people
  3. C;CBad1.7x increased risk for prostate cancerTypical · 0.07% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 60% A;C 33% C;C 7%
  • European ancestry (Utah)A;A 80% A;C 18% C;C 3%
  • Han Chinese (Beijing)A;A 60% A;C 35% C;C 5%
  • Japanese (Tokyo)A;A 52% A;C 37% C;C 11%
  • Yoruba (Nigeria)A;A 42% A;C 45% C;C 13%
  • African ancestry (Southwest US)A;A 56% A;C 39% C;C 5%
  • Chinese (Denver)A;A 66% A;C 28% C;C 6%
  • Gujarati IndianA;A 71% A;C 26% C;C 3%
  • Luhya (Kenya)A;A 33% A;C 45% C;C 22%
  • Mexican ancestry (Los Angeles)A;A 72% A;C 24% C;C 3%
  • Maasai (Kenya)A;A 44% A;C 48% C;C 8%
  • TuscanA;A 82% A;C 16% C;C 2%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs7017300 is one of 4 tightly linked SNPs in the "locus 1" region of 8q24 chromosomal region, which has been linked in several studies to prostate cancer, initially through rs1447295. In a study of 1,563 patients of European ancestry, the odds ratio for prostate cancer associated with risk genotypes of locus 1 were reported as 1.70 (CI: 1.39-2.07). Two other regions of chromosome 8q24 were also studied.

Source and license

Adapted from rs7017300 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.