rs7027989

A SNP in the MTAP gene on chromosome 9. Its most notable genotype is A;A: 1.26x increased myocardial infarction risk

Gene
MTAP
Location
Chr 921,817,755 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.26x increased myocardial infarction riskTypical · 0.013% of people
  2. A;GBad1.26x increased myocardial infarction riskTypical · 0.037% of people
  3. G;GNot ratednormalTypical · 0.050% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 13% A;G 37% G;G 50%
  • European ancestry (Utah)A;A 25% A;G 50% G;G 26%
  • Han Chinese (Beijing)A;A 4% A;G 31% G;G 65%
  • Japanese (Tokyo)A;A 20% A;G 47% G;G 33%
  • Yoruba (Nigeria)A;A 0% A;G 23% G;G 77%
  • African ancestry (Southwest US)A;A 5% A;G 30% G;G 65%
  • Chinese (Denver)A;A 4% A;G 30% G;G 66%
  • Gujarati IndianA;A 40% A;G 50% G;G 11%
  • Luhya (Kenya)A;A 2% A;G 21% G;G 77%
  • Mexican ancestry (Los Angeles)A;A 10% A;G 52% G;G 38%
  • Maasai (Kenya)A;A 4% A;G 19% G;G 77%
  • TuscanA;A 30% A;G 51% G;G 19%

Other MTAP SNPs

All MTAP SNPs

Notes

From SNPedia

Notes

rs7027989 is a SNP in the methylthioadenosine phosphorylase MTAP gene. A study of 432 Han Chinese patients with myocardial infarctions concluded that male subjects carrying a rs7027989(A) allele were at 1.26x increased risk (for MI).

Source and license

Adapted from rs7027989 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.