rs7091565

A SNP in the ANXA11 gene on chromosome 10. Its most notable genotype is C;C: normal

Gene
ANXA11
Location
Chr 1080,153,805 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
45%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.027% of people
  2. C;TBad1.26x risk of sarcoidosisTypical · 0.050% of people
  3. T;TBad1.26x risk of sarcoidosisTypical · 0.024% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 27% C;T 50% T;T 24%
  • European ancestry (Utah)C;C 28% C;T 47% T;T 25%
  • Han Chinese (Beijing)C;C 33% C;T 53% T;T 14%
  • Japanese (Tokyo)C;C 39% C;T 50% T;T 12%
  • Yoruba (Nigeria)C;C 18% C;T 53% T;T 29%
  • African ancestry (Southwest US)C;C 14% C;T 65% T;T 21%
  • Chinese (Denver)C;C 31% C;T 51% T;T 19%
  • Gujarati IndianC;C 14% C;T 45% T;T 42%
  • Luhya (Kenya)C;C 23% C;T 54% T;T 23%
  • Mexican ancestry (Los Angeles)C;C 30% C;T 42% T;T 28%
  • Maasai (Kenya)C;C 30% C;T 38% T;T 32%
  • TuscanC;C 34% C;T 49% T;T 17%

Conditions, medicines and genes

Other ANXA11 SNPs

All ANXA11 SNPs

Notes

From SNPedia

Notes

499 German individuals with sarcoidosis and 490 controls; Validation in an independent sample 1,649 cases, 1,832 controls. rs2789679: P = 3.0 x 10(-13), rs7091565: P = 1.0 x 10(-5)rs1049550, T > C, R230C was found to be strongly associated with sarcoidosis. rs2789679 P = 3.0 x 10(-13), rs7091565: P = 1.0 x 10(-5), allele-based test). Extensive fine mapping located the association signal to a region between exon 5 and exon 14 of ANXA11. A common nonsynonymous SNP (rs1049550, T > C, R230C) was found to be strongly associated with sarcoidosis

Source and license

Adapted from rs7091565 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.