rs710521

A SNP on chromosome 3. Its most notable genotype is T;T: 1.4x increased risk of developing bladder cancer.

Gene
None listed
Location
Chr 3189,928,144 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
23%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.4x increased risk of developing bladder cancer.Worth knowing · 2.063% of people
  2. C;TNot ratedNormal risk of developing bladder cancer.Minor · 1.533% of people
  3. C;CGoodLower (0.83x) risk of developing bladder cancer.Worth knowing · 2.04% of people

SNPedia records rs710521 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 63% C;T 33% C;C 4%
  • European ancestry (Utah)T;T 45% C;T 47% C;C 8%
  • Han Chinese (Beijing)T;T 61% C;T 34% C;C 6%
  • Japanese (Tokyo)T;T 59% C;T 35% C;C 5%
  • Yoruba (Nigeria)T;T 76% C;T 22% C;C 3%
  • African ancestry (Southwest US)T;T 70% C;T 25% C;C 5%
  • Chinese (Denver)T;T 62% C;T 37% C;C <1%
  • Gujarati IndianT;T 74% C;T 25% C;C 1%
  • Luhya (Kenya)T;T 64% C;T 35% C;C 2%
  • Mexican ancestry (Los Angeles)T;T 55% C;T 40% C;C 5%
  • Maasai (Kenya)T;T 71% C;T 26% C;C 3%
  • TuscanT;T 54% C;T 38% C;C 8%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 190 words

rs710521 is a SNP located in chromosome region 3q38, near the TP63 gene. A study ultimately totaling over 4,000 bladder cancer patients of European ancestry (and 40,000 controls) concluded that individuals carrying two copies of rs710521(A) were at 1.4x increased risk (allele-specific odds ratio = 1.19, p = 1 x 10e-7) for the disease. An additional 1,425 bladder cancer patients, supplemented by a meta-analysis of 5,695 additional cases (and 40,000+ controls), did replicate a (somewhat) increased risk associated with the rs710521(A) allele. The overall odds ratio was 1.18 (OR: 1.12 - 1.25, p < 0.0001). Another study in Chinese populations did not find an increased risk of bladder cancer for this SNP.

T;T

Slightly increased risk of bladder cancer, particularly in Europeans and in people who already have tumors with low risk of progression.

C;T

This is the normal risk of bladder cancer, particularly in Europeans and in people who already have tumors with low risk of progression.

C;C

This slightly lowers the risk of bladder cancer. Particularly in Europeans, and in people who already have tumors with low risk of progression.

Source and license

Adapted from rs710521 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.