rs713041

A SNP in the GPX4 gene on chromosome 19. Its most notable genotype is C;C: normal

Gene
GPX4
Location
Chr 191,106,616 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
40%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.036% of people
  2. C;TBad1.3x increased risk of death if diagnosed with breast cancerTypical · 0.048% of people
  3. T;TBad>1.3x increased risk of death if diagnosed with breast cancerTypical · 0.016% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 36% C;T 48% T;T 16%
  • European ancestry (Utah)C;C 32% C;T 45% T;T 23%
  • Han Chinese (Beijing)C;C 28% C;T 49% T;T 23%
  • Japanese (Tokyo)C;C 37% C;T 48% T;T 15%
  • Yoruba (Nigeria)C;C 52% C;T 40% T;T 8%
  • African ancestry (Southwest US)C;C 54% C;T 39% T;T 7%
  • Chinese (Denver)C;C 34% C;T 47% T;T 19%
  • Gujarati IndianC;C 26% C;T 54% T;T 21%
  • Luhya (Kenya)C;C 47% C;T 45% T;T 8%
  • Mexican ancestry (Los Angeles)C;C 37% C;T 53% T;T 11%
  • Maasai (Kenya)C;C 24% C;T 55% T;T 21%
  • TuscanC;C 23% C;T 52% T;T 26%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Two SNPs associated with the antioxidant GPX4 gene, rs713041 and rs757229, are both somewhat correlated (r 2 =0.61) and are associated with all-cause mortality in breast cancer. The rs713041(T) allele is associated with an increased risk of death following breast cancer diagnosis, with a hazard ratio of 1.27 per rare allele (CI: 1.13-11.43, p=0.0041).

Source and license

Adapted from rs713041 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.