rs7142143

A SNP in the PYGL gene on chromosome 14. Its most notable genotype is C;C: Increased odds of relapse in treated childhood ALL patients

Gene
PYGL
Location
Chr 1450,936,813 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
2%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadIncreased odds of relapse in treated childhood ALL patientsWorth knowing · 2.50% of people
  2. C;TBadIncreased odds of relapse in treated childhood ALL patientsWorth knowing · 2.07% of people
  3. T;TGoodcommon/normalTypical · 0.093% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 8 HapMap populations.

  • AverageC;C 0% C;T 7% T;T 93%
  • European ancestry (Utah)C;C 0% C;T 0% T;T 100%
  • Han Chinese (Beijing)C;C 0% C;T 0% T;T 100%
  • Japanese (Tokyo)C;C 0% C;T 0% T;T 100%
  • Yoruba (Nigeria)C;C 0% C;T 24% T;T 76%
  • African ancestry (Southwest US)C;C 0% C;T 14% T;T 86%
  • Luhya (Kenya)C;C 0% C;T 14% T;T 86%
  • Maasai (Kenya)C;C 0% C;T 6% T;T 94%
  • TuscanC;C 0% C;T 2% T;T 98%

Conditions, medicines and genes

Other PYGL SNPs

All PYGL SNPs

Notes

From SNPedia

Notes

Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia. Each rs7142143(C) allele increases odds of relapse by 3.6x (CI: 2.34-5.57, adjusted p=1.20 × 10e−5) based on a study of 2,500 childhood acute lymphoblastic leukemia patients.

C;C

see rs7142143

C;T

see rs7142143

Source and license

Adapted from rs7142143 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.