rs7171755

A SNP in the REC114 gene on chromosome 15. Its most notable genotype is A;A: very slight descrease in cortical thickness and IQ; see full description

Gene
REC114
Location
Chr 1573,558,239 (GRCh38)
Highest magnitude
1.1Minor
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
49%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadvery slight descrease in cortical thickness and IQ; see full descriptionMinor · 1.122% of people
  2. A;GBadvery slight decrease in cortical thickness and IQ; see full textMinor · 1.149% of people
  3. G;GNot ratedcommon/normalMinor · 1.028% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 22% A;G 49% G;G 28%
  • European ancestry (Utah)A;A 17% A;G 58% G;G 25%
  • Han Chinese (Beijing)A;A 29% A;G 45% G;G 26%
  • Japanese (Tokyo)A;A 26% A;G 52% G;G 22%
  • Yoruba (Nigeria)A;A 20% A;G 52% G;G 28%
  • African ancestry (Southwest US)A;A 11% A;G 53% G;G 37%
  • Chinese (Denver)A;A 30% A;G 46% G;G 24%
  • Gujarati IndianA;A 14% A;G 54% G;G 33%
  • Luhya (Kenya)A;A 32% A;G 49% G;G 19%
  • Mexican ancestry (Los Angeles)A;A 28% A;G 40% G;G 33%
  • Maasai (Kenya)A;A 22% A;G 46% G;G 32%
  • TuscanA;A 20% A;G 48% G;G 32%

Conditions, medicines and genes

Other REC114 SNPs

All REC114 SNPs

Notes

From SNPedia

Show notes, about 130 words

rs7171755 is a SNP near the synaptic cell adhesion glycoprotein-encoding NPTN gene. A study of ~1,500 adolescents determined that the rs7171755(A) allele is associated with a slightly thinner left hemisphere cortex and also a slight decrease in verbal and nonverbal intelligence (IQ). The differences were really quite slight; each copy of the risk allele decreased cortical thickness by 0.7%, and decreased verbal and nonverbal IQ by 1.8 and 1.4 points, respectively. This study awaits independent replication. Also, note that eight SNPs in the NPTN locus were reported as jointly showing significant association with cortical thickness in addition to rs7171755: rs7176637, rs11854138, rs8028749, rs12185108, rs1564492, rs899981, rs7178269 and rs4075802.

Source and license

Adapted from rs7171755 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.