rs7190458
A SNP in the BCAR1 gene on chromosome 16. Its most notable genotype is A;A: Higher pancreatic cancer risk
- Gene
- BCAR1
- Location
- Chr 1675,229,763 (GRCh38)
- Highest magnitude
- 2.1Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadHigher pancreatic cancer risk
- A;GBadSlightly higher pancreatic cancer risk
- G;GGoodcommon genotype
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageA;A 2% A;G 19% G;G 79%
- European ancestry (Utah)A;A <1% A;G 10% G;G 89%
- Han Chinese (Beijing)A;A 0% A;G 4% G;G 96%
- Japanese (Tokyo)A;A 0% A;G 3% G;G 97%
- Yoruba (Nigeria)A;A 10% A;G 43% G;G 47%
- African ancestry (Southwest US)A;A 2% A;G 40% G;G 58%
- Chinese (Denver)A;A 0% A;G 6% G;G 95%
- Luhya (Kenya)A;A 7% A;G 32% G;G 61%
- Mexican ancestry (Los Angeles)A;A 0% A;G 14% G;G 86%
- Maasai (Kenya)A;A 5% A;G 31% G;G 64%
- TuscanA;A 0% A;G 5% G;G 95%
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
A 2014 study "Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer" of 7,683 European cases and 14,397 controls found the minor allele rs7190458(A) in BCAR1 (breast cancer anti-estrogen resistance 1) conferring risk of statistically genome-wide significance (per-allele odds ratio (OR) = 1.46, 95% confidence interval (CI) 1.30-1.65, P = 1.1E-10) for Pancreatic cancer.
Source and license
Adapted from rs7190458 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.