rs721048

A SNP in the EHBP1 gene on chromosome 2. Its most notable genotype is A;A: slightly increased prostate cancer risk

Gene
EHBP1
Location
Chr 262,904,596 (GRCh38)
Highest magnitude
1.9Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBadslightly increased prostate cancer riskMinor · 1.9<1% of people
  2. A;GNot ratedNo summary available.Typical · 0.015% of people
  3. G;GGoodnormalTypical · 0.085% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A <1% A;G 15% G;G 85%
  • European ancestry (Utah)A;A <1% A;G 26% G;G 74%
  • Han Chinese (Beijing)A;A 0% A;G 6% G;G 94%
  • Japanese (Tokyo)A;A <1% A;G 12% G;G 87%
  • Yoruba (Nigeria)A;A 0% A;G 0% G;G 100%
  • African ancestry (Southwest US)A;A 0% A;G 12% G;G 88%
  • Chinese (Denver)A;A 0% A;G 6% G;G 95%
  • Gujarati IndianA;A 2% A;G 22% G;G 76%
  • Luhya (Kenya)A;A 0% A;G 4% G;G 96%
  • Mexican ancestry (Los Angeles)A;A 2% A;G 28% G;G 71%
  • Maasai (Kenya)A;A <1% A;G 21% G;G 79%
  • TuscanA;A 2% A;G 25% G;G 74%

Conditions, medicines and genes

Notes

From SNPedia

Notes

shows a significantly stronger association with more aggressive forms of prostate cancer (odds ratios (OR) = 1.15; P = 7.7 x 10(-9)).

Source and license

Adapted from rs721048 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.