rs7221412

A SNP in the LOC105376799 gene on chromosome 17. Its most notable genotype is A;A: Early riser. Wakes up 1 hour earlier than those with GG genotype.

Gene
LOC105376799
Location
Chr 178,137,696 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableNot ratedEarly riser. Wakes up 1 hour earlier than those with GG genotype.Worth knowing · 2.049% of people
  2. A;GNot ratedIntermediate riser. Wakes up at a time between the AA and GG genotypes.Worth knowing · 2.039% of people
  3. G;GNot ratedLate riser. Wakes up 1 hour later than those with AA genotype.Worth knowing · 2.012% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 49% A;G 39% G;G 12%
  • European ancestry (Utah)A;A 28% A;G 50% G;G 22%
  • Han Chinese (Beijing)A;A 75% A;G 25% G;G <1%
  • Japanese (Tokyo)A;A 72% A;G 28% G;G 0%
  • Yoruba (Nigeria)A;A 44% A;G 38% G;G 18%
  • African ancestry (Southwest US)A;A 33% A;G 51% G;G 16%
  • Chinese (Denver)A;A 80% A;G 20% G;G 0%
  • Gujarati IndianA;A 64% A;G 30% G;G 6%
  • Luhya (Kenya)A;A 34% A;G 48% G;G 18%
  • Mexican ancestry (Los Angeles)A;A 50% A;G 40% G;G 10%
  • Maasai (Kenya)A;A 28% A;G 49% G;G 23%
  • TuscanA;A 36% A;G 49% G;G 15%

Notes

From SNPedia

Show notes, about 170 words

A common polymorphism near PER1 and the timing of human behavioral rhythms. Study showed that it had influence on wake-up times, as well as time of day that death occurs. Suggests that common (but unidentified) polymorphisms may be associated with a preference for daytime or nighttime activity. rs7221412 appears to sit in a haplotype block and is flanked by rs9914077 and rs2585408

A;A

Research also suggests, then you are also more likely to die on a morning, shortly before 11am. http://www.theatlantic.com/health/archive/2012/11/you-are-most-likely-to-die-at-11-am/265427/

A;G

Research also suggests, then you are also more likely to die on a morning, shortly before 11am. http://www.theatlantic.com/health/archive/2012/11/you-are-most-likely-to-die-at-11-am/265427/

G;G

Research also suggests, then you while most people are more likely to die shortly before 11am, you are more likely to die later in the day. http://www.theatlantic.com/health/archive/2012/11/you-are-most-likely-to-die-at-11-am/265427/

Source and license

Adapted from rs7221412 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.