rs7234029

A SNP in the PTPN2 gene on chromosome 18. Its most notable genotype is G;G: Slightly increased (1.6x) risk for Crohn's disease

Gene
PTPN2
Location
Chr 1812,877,061 (GRCh38)
Highest magnitude
1.6Minor
Tested on
23andMe, AncestryDNA
Minor allele frequency
29%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AGoodcommon/normalTypical · 0.048% of people
  2. A;GBadSlightly increased (1.36x) risk for Crohn's diseaseMinor · 1.337% of people
  3. G;GMost notableBadSlightly increased (1.6x) risk for Crohn's diseaseMinor · 1.615% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 48% A;G 37% G;G 15%
  • European ancestry (Utah)A;A 81% A;G 16% G;G 3%
  • Han Chinese (Beijing)A;A 50% A;G 42% G;G 8%
  • Japanese (Tokyo)A;A 37% A;G 45% G;G 18%
  • Yoruba (Nigeria)A;A 16% A;G 49% G;G 35%
  • African ancestry (Southwest US)A;A 25% A;G 49% G;G 26%
  • Chinese (Denver)A;A 54% A;G 38% G;G 8%
  • Gujarati IndianA;A 71% A;G 26% G;G 3%
  • Luhya (Kenya)A;A 19% A;G 50% G;G 31%
  • Mexican ancestry (Los Angeles)A;A 74% A;G 24% G;G 2%
  • Maasai (Kenya)A;A 23% A;G 52% G;G 25%
  • TuscanA;A 77% A;G 22% G;G 2%

Other PTPN2 SNPs

All PTPN2 SNPs

Source and license

Adapted from rs7234029 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.