rs726070
A SNP in the LOC101928103 gene on chromosome 2. Its most notable genotype is T;T: Two copies of a variant now thought likely to benign
- Gene
- LOC101928103
- Location
- Chr 2214,948,607 (GRCh38)
- Highest magnitude
- 1.0Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 2%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot ratedTwo copies of a variant now thought likely to benign
- C;TNot ratedCarrier of a variant now thought likely to be benign
- C;CGoodcommon in clinvar
SNPedia records rs726070 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 0% C;T 4% C;C 96%
- European ancestry (Utah)T;T 0% C;T 7% C;C 93%
- Han Chinese (Beijing)T;T 0% C;T 4% C;C 96%
- Japanese (Tokyo)T;T 0% C;T 4% C;C 97%
- Yoruba (Nigeria)T;T 0% C;T 1% C;C 99%
- African ancestry (Southwest US)T;T 0% C;T 4% C;C 96%
- Chinese (Denver)T;T 0% C;T <1% C;C 99%
- Gujarati IndianT;T 0% C;T 4% C;C 96%
- Luhya (Kenya)T;T 0% C;T <1% C;C 99%
- Mexican ancestry (Los Angeles)T;T 0% C;T 9% C;C 91%
- Maasai (Kenya)T;T 0% C;T <1% C;C 99%
- TuscanT;T 0% C;T 5% C;C 95%
Related
Notes
From SNPedia
Show notes, about 120 words
aka c.7093G>A (p.Asp2365Asn) The variant allele was reported over a decade ago as being a recessive mutation associated with a form of ichthyosis; however, more recent annotations have come to the conclusion that it is actually likely to be benign, in part since it's seen far more frequently than would be expected given how rare the actual condition is.
T;T
Over a decade ago, the variant allele was considered a recessive mutation associated with a form of ichthyosis; the current consensus is that it's actually likely to be benign.
C;T
Over a decade ago, the variant allele was considered a recessive mutation associated with a form of ichthyosis; the current consensus is that it's actually likely to be benign.
Source and license
Adapted from rs726070 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.