rs72613567

A SNP in the HSD17B13 gene on chromosome 4. Its most notable genotype is A;A: Lower risk (~1/2 roughly) for chronic liver disease

Gene
HSD17B13
Location
Chr 487,310,240 (GRCh38)
Highest magnitude
3.5Important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodLower risk (~1/2 roughly) for chronic liver diseaseImportant · 3.5
  2. A;TGoodSomewhat lower risk for chronic liver diseaseImportant · 3.0
  3. T;TGoodcommon/normalTypical · 0.0

On SNPedia: (A;A), (A;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Notes

From SNPedia

Notes

The rs72613567(A) variant appears to reduce risk of alcoholic liver disease by ~42% (CI: 20 to 58%) among heterozygotes and by 53% (CI:3 to 77%) among homozygotes, as well as reducing risk for (1) nonalcoholic liver disease (by 17%, CI: 8 - 25) among heterozygotes and (by 30%, CI: 13 - 43) among homozygotes, (2) alcoholic cirrhosis (by 42%, CI: 14 - 61) among heterozygotes and (by 73%, CI: 15 - 91) among homozygotes, and (3) nonalcoholic cirrhosis (by 26%, CI: 7 - 40) among heterozygotes and (by 49%, CI: 15 - 69) among homozygotes, based on a study of 40,000+ Geisinger participants.

A;A

see citation and discussion via main rs-page

A;T

see citation and discussion via main rs-page

Source and license

Adapted from rs72613567 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.