rs732609

A SNP in the TPO gene on chromosome 2. Its most notable genotype is A;A: common in clinvar

Gene
TPO
Location
Chr 21,496,155 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
47%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodcommon in clinvarTypical · 0.026% of people

On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 26%
  • European ancestry (Utah)A;A 41%
  • Han Chinese (Beijing)A;A 35%
  • Japanese (Tokyo)A;A 25%
  • Yoruba (Nigeria)A;A 6%
  • African ancestry (Southwest US)A;A 19%
  • Chinese (Denver)A;A 39%
  • Gujarati IndianA;A 31%
  • Luhya (Kenya)A;A 10%
  • Mexican ancestry (Los Angeles)A;A 36%
  • Maasai (Kenya)A;A 10%
  • TuscanA;A 35%

Other TPO SNPs

All TPO SNPs

Notes

From SNPedia

Notes

. This article gave complex data. The heterozygous polymorphism (AC) gave 0.87x lower risk of hypothyroidism among Italians, but 2x increased risk among Spanish. Thyroid cancer risk 0.93 among Italians, 1.7 among Spanish.

Source and license

Adapted from rs732609 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.