rs735665

A SNP in the GRAMD1B gene on chromosome 11. Its most notable genotype is G;G: common on affy axiom data

Gene
GRAMD1B
Location
Chr 11123,490,689 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodcommon on affy axiom dataTypical · 0.087% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 87%
  • European ancestry (Utah)G;G 70%
  • Han Chinese (Beijing)G;G 99%
  • Japanese (Tokyo)G;G 99%
  • Yoruba (Nigeria)G;G 97%
  • African ancestry (Southwest US)G;G 96%
  • Chinese (Denver)G;G 98%
  • Gujarati IndianG;G 79%
  • Luhya (Kenya)G;G 96%
  • Mexican ancestry (Los Angeles)G;G 53%
  • Maasai (Kenya)G;G 98%
  • TuscanG;G 69%

Conditions, medicines and genes

Notes

From SNPedia

Notes

23andMe blog chronic lymphocytic leukemia *rs735665 A 1.45 news Slager and colleagues validated these in an independent sample of patients. The strongest association was for rs735665 on 11q24, where the risk was 50 percent higher. This was closely followed by a 39 percent increased risk associated with rs9378805 on 6p25. Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Genetic susceptibility for chronic lymphocytic leukemia among Chinese in Hong Kong.

Source and license

Adapted from rs735665 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.