rs73568641

A SNP on chromosome 6. Its most notable genotype is C;C: For African Americans in treatment, possible methadone dose adjustment

Gene
None listed
Location
Chr 6153,704,004 (GRCh38)
Highest magnitude
1.9Minor
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedFor African Americans in treatment, possible methadone dose adjustmentMinor · 1.9
  2. C;TNot ratedFor African Americans in treatment, possible methadone dose adjustmentMinor · 1.9
  3. T;TGoodcommon/normalTypical · 0.0

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs73568641 represents a variant located ~300kb away from the OPRM1 gene on chromosome 6. A study of ~400 African-Americans reported a genome-wide significant association between therapeutic methadone dose as used to treat opioid dependence (mean=68.0 mg, s.d.=30.1 mg) and rs73568641 (p=2.8 × 10e−8), with each minor rs73568641(C) allele corresponding to an additional maintenance dose of ~20 mg/day (of oral methadone). This association was not seen in European-Americans.

C;C

see rs73568641

C;T

see rs73568641

Source and license

Adapted from rs73568641 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.