rs742710

A SNP in the CHGB gene on chromosome 20. Its most notable genotype is C;C.

Gene
CHGB
Location
Chr 205,923,382 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
15%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.070% of people

SNPedia records rs742710 on the minus strand: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 70%
  • European ancestry (Utah)C;C 94%
  • Han Chinese (Beijing)C;C 65%
  • Japanese (Tokyo)C;C 82%
  • Yoruba (Nigeria)C;C 54%
  • African ancestry (Southwest US)C;C 67%
  • Chinese (Denver)C;C 67%
  • Gujarati IndianC;C 72%
  • Luhya (Kenya)C;C 50%
  • Mexican ancestry (Los Angeles)C;C 59%
  • Maasai (Kenya)C;C 67%
  • TuscanC;C 90%

Notes

From SNPedia

Notes

23andMe blog 2x risk of ALS Chromogranin B P413L variant as risk factor and modifier of disease onset for amyotrophic lateral sclerosis. The P413L chromogranin B variation in French patients with sporadic amyotrophic lateral sclerosis.

Source and license

Adapted from rs742710 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.